Ayala Pharmaceuticals Inc (ADXS)

[huskercatman123]

Will also possibly work with LM as the delivery vehicle?

"Nevertheless, although the mRNA delivery system was more effective than the plasmid DNA delivery strain, it was still not as effective as the Listeria strains that endogenously expressed and secreted the tumor antigen [56]. Clearly, despite a decade of research developing Listeria monocytogenes as a vector for the delivery of eukaryotic expression systems, further improvements are required for these strategies to exceed or match the effectiveness of Listeria as a protein delivery system (55, 56). Nevertheless such efforts are important since they could overcome some of the difficulties associated with expression and secretion of large, hydrophobic proteins by Listeria, thus broadening the targets for Listeria based tumor immunotherapy."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411241/